Workload:
90 h
|
Module Number BIOINF4230 (entspricht BIO-4230) |
Module Title Applied Structure-Based Drug Design |
Lecture Type(s) Practical Course |
|---|---|---|
| ECTS | 3 | |
|
Work load - Contact time - Self study |
Workload:
90 h Class time:
30 h / 2 SWS Self study:
60 h |
|
| Duration | 1 Semester | |
| Frequency | Irregular | |
| Language of instruction | English | |
| Type of Exam | Written elaboration and presentation based on it |
|
| Content | This module deals with the practical application of basic techniques and tools of computer-aided drug design. The program packages BALLView, VMD, Glide, Prime and Modeller are used for this purpose. Initially, the focus is on the preparation and visualization of 3D structures. In addition, specific intramolecular interactions of protein-ligand complexes are examined in more detail and selected ligands are docked into a pharmaceutically interesting target. The second part of the lab focuses on virtual high-throughput screening and rational structure-based drug design. |
|
| Objectives | (1) Students are fundamentally able to handle standard tools of structure-based drug design, (2) are familiar with the practical handling of protein and ligand structures and (3) are able to interpret the results of these tools and techniques and critically assess them with regard to their relevance. |
|
| Allocation of credits / grading |
Type of Class
Status
SWS
Credits
Type of Exam
Exam duration
Evaluation
Calculation
of Module (%)
Practical Course
P
o
3
3.0
tp,
op
g
100
|
|
| Prerequisite for participation | There are no specific prerequisites. | |
| Lecturer / Other | Kohlbacher | |
| Literature | Materialien werden zur Verfügung gestellt. |
|
| Last offered | unknown | |
| Planned for | currently not planned | |
| Assigned Study Areas | BIO-PRAK, MEDZ-BIOMED, MEDZ-RES | |